Based on your data from Parts A & C above, calculate the ratio of PEG base relative to cocoa butter.Product selection permitted Dispense as written Using the PEG suppository base above, prepare the following prescription (prepare for 8 suppositories, but dispense only 6). Fusion Molding – Using an Estimated Density Factor Carefully remove excess with a hot spatula or knife then remove the suppositories from the mold.ĭ.
Let stand at room temperature 30 minutes, or until solid.
Melt 30 g of PEG 3350 first on a steam bath or hot plate, then reduce the heat and mix in 20 g of PEG 400. To calibrate the mold with PEG suppository base: For this calibration exercise, use 50 g of the following proportions of PEG 3350 and PEG 400. 
PEG Base Suppositories have many different PEGs and proportions. Calibration of Suppository Molds with PEG Base
Carefully remove excess with a hot spatula or knife. Overfill the cavities in the mold, cool at room temperature for 30 minutes, and then place in a refrigerator 15-20 minutes if the suppositories have not completely congealed. Remove from the heat and allow the mixture to cool near the melting point before pouring into the mold. Do not allow the temperature to get above 90 – 95☌, as the color will darken. After the gelatin has been added, continue heating for another 40 – 50 minutes. Gently stir in the gelatin to avoid incorporating air in the mixture. Mix the glycerin and water together and heat on a steam bath or hot plate for 5 minutes. Lubricate the mold with light mineral oil. To calibrate the mold with glycerinated gelatin suppository base: Use 75 g of the suppository base for this calibration exercise. Glycercinated Gelatin Suppositories have the following proportions of glycerin, gelatin, and water. Calibration of Suppository Molds with Glycerinated Gelatin Base Calculate the average suppository weight.ī. Using only perfect specimens, weigh the suppositories and record the total weight. Clean entire mold thoroughly with soap and water. This will damage the matching mold faces which have been accurately machined to give a tight seal and eliminate breakage. CAUTION: Never open mold by prying at parting line with knife, spatula, or other instrument. Then rest entire assembly on the brass posts and apply pressure to lower half of mold. Separate mold by removing the three wing nuts from the ends of the brass screws. Carefully remove the excess with a hot spatula or knife scarped flat across the top surface of the mold. If it is not solidified at that time, put in a refrigerator for an additional 30 minutes. 
Allow the cocoa butter to cool at room temperature for 30 minutes.This is necessary to allow for shrinkage during cooling. Overfill cavities until there is a slight overflow of cocoa butter onto the surface of the mold. Remove the mixture from the heat and fill the mold cavities.
Melt approximately 30 g of cocoa butter on a steam bath or hot plate but NOT more than 35☌.Apply a light film of glycerin to the cavities with a cotton applicator.Use the following procedure to calibrate the mold with cocoa butter. Calibration of Suppository Molds with Cocoa Butter Preparation of Suppositories: Labs Laboratory Procedure BE SURE TO USE THE SAME MOLD THROUGHOUT THE EXPERIMENT.
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